Iron accumulationin the mitochondria due to the absence of the frataxin protein is associated with a high oxidative stress in the cells of patients with FRDA. The apoptosis of the neurons of the cerebellum and dorsal ganglia represents the last stage of a neurodegenerative process triggered by chronic exposure to reactive oxygen species (ROS). In mesenchymal stem cells of FRDA patients, the Au8-pXs gold nanoclusters restore proliferative capacity, better oxidative respiration and a decreaseof ROS production.
Biotech
Gold Nanoparticles for the treatment of Mitochondrial Diseases
Novystem Nanoclusters are highly effective in reducing neuronal loss and induce amplification of Purkinje cells compared to untreated mice group.
